GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.
5-ht5b receptor
Not curated in GtoImmuPdb
Target id: 648
Nomenclature: 5-ht5b receptor
Family: 5-Hydroxytryptamine receptors
Annotation status:
Awaiting annotation
» Email us
Contents:
- Quaternary Structure
- Gene and Protein Information
- Previous and Unofficial Names
- Database Links
- Selected 3D Structures
- Associated Proteins
- Functional Characteristics
- Natural/Endogenous Ligands
- Rank order lists
- Activators
- Inhibitors
- Gating Inhibitors
- Agonists
- Antagonists
- Channel Blockers
- Allosteric Modulators
- Antibodies
- Other Binding Ligands
- Whole Organism Assay Data
- Large-scale Ligand Screening Data
- Immunopharmacology Comments
- Immuno Cell Type Associations
- Immuno Process Associations
- Immuno Disease Associations
- Malaria Pharmacology Comments
- Transduction Mechanisms
- Tissue Distribution
- Expression Datasets
- Functional Assays
- Physiological Functions
- Physiological Consequences of Altering Gene Expression
- Xenobiotics Influencing Gene Expression
- Phenotypes, Alleles and Disease Models
- Clinically-Relevant Mutations and Pathophysiology
- Gene Expression and Pathophysiology
- Biologically Significant Variants
- General Comments
- Available Assays
- References
- Contributors
- How to cite this page
Gene and Protein Information  |
||||||
| class A G protein-coupled receptor: pseudogene in man | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | - | 2q14.1 | HTR5BP | 5-hydroxytryptamine receptor 5B, pseudogene | |
| Mouse | 7 | 370 | 1 52.98 cM | Htr5b | 5-hydroxytryptamine (serotonin) receptor 5B | |
| Rat | 7 | 370 | 13p12 | Htr5b | 5-hydroxytryptamine (serotonin) receptor 5B | |
| Gene and Protein Information Comments | ||||||
| The human orthologue of the mouse 5-ht5b receptor is non-functional due to interruption of the gene by stop codons. | ||||||
| Previous and Unofficial Names |
| GPR134 | HTR5B | G protein-coupled receptor 134 | 5Ht5b | MR22 | serotonin receptor 5B | 5-hydroxytryptamine (serotonin) receptor 5B, pseudogene |
| Database Links |
|
| Specialist databases | |
| GPCRdb | 5ht5b_mouse (Mm), 5ht5b_rat (Rn) |
| Other databases | |
| Alphafold | P31387 (Mm), P35365 (Rn) |
| ChEMBL Target | CHEMBL2619 (Rn) |
| Ensembl Gene | ENSG00000125631 (Hs), ENSMUSG00000050534 (Mm), ENSRNOG00000002549 (Rn) |
| Entrez Gene | 645694 (Hs), 15564 (Mm), 79247 (Rn) |
| Human Protein Atlas | ENSG00000125631 (Hs) |
| KEGG Gene | hsa:645694 (Hs), mmu:15564 (Mm), rno:79247 (Rn) |
| RefSeq Nucleotide | NG_008325 (Hs), NM_010483 (Mm), NM_024395 (Rn) |
| RefSeq Protein | NP_077371 (Rn) |
| UniProtKB | P31387 (Mm), P35365 (Rn) |
| Wikipedia | HTR5BP (Hs) |
| Natural/Endogenous Ligands |
| 5-hydroxytryptamine |
Download all structure-activity data for this target as a CSV file 
| Agonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
References
1. Matthes H, Boschert U, Amlaiky N, Grailhe R, Plassat JL, Muscatelli F, Mattei MG, Hen R. (1993) Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Mol Pharmacol, 43 (3): 313-9. [PMID:8450829]
2. Waeber C, Grailhe R, Yu XJ, Hen R, Moskowitz MA. (1998) Putative 5-ht5 receptors: localization in the mouse CNS and lack of effect in the inhibition of dural protein extravasation. Ann N Y Acad Sci, 861: 85-90. [PMID:9928243]
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License