Basic helix-loop-helix (BHLH) TFs

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Basic helix-loop-helix (BHLH) TFs

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Targets

3326

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transcription factor 4 Show summary »« Hide summary

Target Id	3326
Nomenclature	transcription factor 4
Previous and unofficial names	class B basic helix-loop-helix protein 19 (bHLHb19) \| E2-2 \| immunoglobulin transcription factor 2 (ITF2) \| SEF2-1B \| SL3-3 enhancer factor 2
Genes	TCF4 (Hs), Tcf4 (Mm), Tcf4 (Rn)
Ensembl ID	ENSG00000196628 (Hs), ENSMUSG00000053477 (Mm), ENSRNOG00000012405 (Rn)
UniProtKB AC	P15884 (Hs), Q60722 (Mm), Q62655 (Rn)
Comment	A transcription factor that preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3' to initiate transcription. Participates in initiating neuronal differentiation.

Citation information

Database page citation:

Basic helix-loop-helix (BHLH) TFs. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1121.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.