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CD86

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2745

Nomenclature: CD86

Family: Other immune checkpoint proteins, CD molecules

Annotation status:  image of a red circle Awaiting annotation  » Email us

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 329 3q13.33 CD86 CD86 molecule
Mouse 1 309 16 25.72 cM Cd86 CD86 antigen
Rat - 313 11q22 Cd86 CD86 molecule
Previous and Unofficial Names Click here for help
CD86 antigen
Database Links Click here for help
Alphafold P42081 (Hs), P42082 (Mm)
CATH/Gene3D 2.60.40.10
ChEMBL Target CHEMBL2364156 (Hs)
DrugBank Target P42081 (Hs)
Ensembl Gene ENSG00000114013 (Hs), ENSMUSG00000022901 (Mm), ENSRNOG00000038835 (Rn)
Entrez Gene 942 (Hs), 12524 (Mm), 56822 (Rn)
Human Protein Atlas ENSG00000114013 (Hs)
KEGG Gene hsa:942 (Hs), mmu:12524 (Mm), rno:56822 (Rn)
OMIM 601020 (Hs)
Pharos P42081 (Hs)
RefSeq Nucleotide NM_175862 (Hs), NM_019388 (Mm), NM_020081 (Rn)
RefSeq Protein NP_787058 (Hs), NP_062261 (Mm), NP_064466 (Rn)
UniProtKB P42081 (Hs), P42082 (Mm)
Wikipedia CD86 (Hs)
Immunopharmacology Comments
CD86 (B7-2) is a type I membrane immunoglobulin. It is expressed on antigen-presenting cells and in association with CD80 provides the costimulatory signal necessary for T cell activation and survival. CD86 interacts with CD28 or CTLA-4 on T cells. It is the interaction with CTLA-4 that is targeted by the approved immunosuppresive drugs abatacept and belatacept.
Cell Type Associations
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:   macrophage (CL:0000235)
Comment:  CD86 is expressed on antigen-presenting cells.
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
Immuno Cell Type:  B cells
Cell Ontology Term:   B cell (CL:0000236)
Immuno Disease Associations
Disease Name:  Rheumatoid arthritis
Disease Synonyms:  no synonyms
Comment:  CD86 is a primary target of the ligand abatacept, which is clinically approved for the treatment of rheumatoid arthritis.
Disease X-refs:  Disease Ontology: DOID:7148
OMIM: 180300
References:  3
Disease Name:  Graft versus host disease
Disease Synonyms:  no synonyms
Comment:  CD86 is a primary target of the approved anti-rejection drug belatacept.
General Comments
This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.

References

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1. Latek R, Fleener C, Lamian V, Kulbokas 3rd E, Davis PM, Suchard SJ, Curran M, Vincenti F, Townsend R. (2009) Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation. Transplantation, 87 (6): 926-33. [PMID:19300198]

2. Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA. (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med, 174 (3): 561-9. [PMID:1714933]

3. Vicente Rabaneda EF, Herrero-Beaumont G, Castañeda S. (2013) Update on the use of abatacept for the treatment of rheumatoid arthritis. Expert Rev Clin Immunol, 9 (7): 599-621. [PMID:23899231]

How to cite this page

Other immune checkpoint proteins: CD86. Last modified on 28/06/2022. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2745.