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CD80

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2744

Nomenclature: CD80

Family: Other immune checkpoint proteins, CD molecules

Annotation status:  image of a red circle Awaiting annotation  » Email us

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 288 3q13.33 CD80 CD80 molecule
Mouse 1 306 16 26.86 cM Cd80 CD80 antigen
Rat - 321 11q21 Cd80 Cd80 molecule
Previous and Unofficial Names Click here for help
B-lymphocyte activation antigen B7 | CD28LG | CD80 antigen
Database Links Click here for help
Alphafold P33681 (Hs), Q00609 (Mm)
CATH/Gene3D 2.60.40.10
ChEMBL Target CHEMBL2364157 (Hs)
DrugBank Target P33681 (Hs)
Ensembl Gene ENSG00000121594 (Hs), ENSMUSG00000075122 (Mm), ENSRNOG00000001527 (Rn)
Entrez Gene 941 (Hs), 12519 (Mm), 25408 (Rn)
Human Protein Atlas ENSG00000121594 (Hs)
KEGG Gene hsa:941 (Hs), mmu:12519 (Mm), rno:25408 (Rn)
OMIM 112203 (Hs)
Pharos P33681 (Hs)
RefSeq Nucleotide NM_005191 (Hs), NM_009855 (Mm), NM_012926 (Rn)
RefSeq Protein NP_005182 (Hs), NP_033985 (Mm), NP_037058 (Rn)
UniProtKB P33681 (Hs), Q00609 (Mm)
Wikipedia CD80 (Hs)
Immunopharmacology Comments
CD80 (B7-1) is expressed on dendritic cells and activated B cells and monocytes. It is required to provide a costimulatory signal necessary for T cell activation and survival. CD80 works in concert with CD86 to prime T cells. CD80 binds CD28 and CTLA-4 on T cells. It is the interaction with CTLA-4 that is targeted by the approved immunosuppresive drugs abatacept and belatacept.
Cell Type Associations
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:   macrophage (CL:0000235)
monocyte (CL:0000576)
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
Immuno Cell Type:  B cells
Cell Ontology Term:   B cell (CL:0000236)
Immuno Cell Type:  T cells
Immuno Disease Associations
Disease Name:  Allograft rejection
Disease Synonyms:  no synonyms
Comment:  CD80 is a primary target of the approved anti-rejection drug belatacept.
Disease Name:  Rheumatoid arthritis
Disease Synonyms:  no synonyms
Comment:  CD80 is a primary target of the ligand abatacept, which is clinically approved for the treatment of rheumatoid arthritis.
Disease X-refs:  Disease Ontology: DOID:7148
OMIM: 180300
References:  3
General Comments
This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.

References

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1. Latek R, Fleener C, Lamian V, Kulbokas 3rd E, Davis PM, Suchard SJ, Curran M, Vincenti F, Townsend R. (2009) Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation. Transplantation, 87 (6): 926-33. [PMID:19300198]

2. Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA. (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med, 174 (3): 561-9. [PMID:1714933]

3. Vicente Rabaneda EF, Herrero-Beaumont G, Castañeda S. (2013) Update on the use of abatacept for the treatment of rheumatoid arthritis. Expert Rev Clin Immunol, 9 (7): 599-621. [PMID:23899231]

How to cite this page

Other immune checkpoint proteins: CD80. Last modified on 28/06/2022. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2744.