legumain

Not curated in GtoImmuPdb

Target id: 2380

Nomenclature: legumain

Annotation status: Awaiting annotation » Email us

Quaternary Structure
Gene and Protein Information
Previous and Unofficial Names
Database Links
Selected 3D Structures
Associated Proteins
Enzyme Reaction
Substrates and Reaction Kinetics
Products
Cofactors
Functional Characteristics
Natural/Endogenous Ligands
Rank order lists
Activators
Inhibitors
Gating Inhibitors
Agonists
Antagonists
Channel Blockers
Allosteric Modulators
Antibodies
Other Binding Ligands
Whole Organism Assay Data
Large-scale Ligand Screening Data
Immunopharmacology Comments
Immuno Cell Type Associations
Immuno Process Associations
Immuno Disease Associations
Malaria Pharmacology Comments
Tissue Distribution
Expression Datasets
Functional Assays
Physiological Functions
Physiological Consequences of Altering Gene Expression
Xenobiotics Influencing Gene Expression
Phenotypes, Alleles and Disease Models
Clinically-Relevant Mutations and Pathophysiology
Gene Expression and Pathophysiology
Biologically Significant Variants
General Comments
Available Assays
References
Contributors
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Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	433	14q32.12	LGMN	legumain
Mouse	-	435	12 E	Lgmn	legumain
Rat	-	435	6q32	Lgmn	legumain

Previous and Unofficial Names
AEP1 \| asparagine endo peptidase \| asparagine endopeptidase \| asparaginyl endopeptidase 1 \| LGMN1 \| protease, cysteine 1 \| Prsc1

Previous and Unofficial Names

Database Links
Specialist databases
MEROPS	C13.004 (Hs)
Other databases
Alphafold	Q99538 (Hs), O89017 (Mm), Q9R0J8 (Rn)
BRENDA	3.4.22.34
ChEMBL Target	CHEMBL4244 (Hs), CHEMBL1949492 (Mm)
Ensembl Gene	ENSG00000100600 (Hs), ENSMUSG00000021190 (Mm), ENSRNOG00000007089 (Rn)
Entrez Gene	5641 (Hs), 19141 (Mm), 63865 (Rn)
Human Protein Atlas	ENSG00000100600 (Hs)
KEGG Enzyme	3.4.22.34
KEGG Gene	hsa:5641 (Hs), mmu:19141 (Mm), rno:63865 (Rn)
OMIM	602620 (Hs)
Pharos	Q99538 (Hs)
RefSeq Nucleotide	NM_005606 (Hs), NM_001008530 (Hs), NM_011175 (Mm), NM_022226 (Rn)
RefSeq Protein	NP_001008530 (Hs), NP_005597 (Hs), NP_035305 (Mm), NP_071562 (Rn)
UniProtKB	Q99538 (Hs), O89017 (Mm), Q9R0J8 (Rn)
Wikipedia	LGMN (Hs)

Enzyme Reaction

EC Number: 3.4.22.34

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Inhibitors

Key to terms and symbols

View all chemical structures

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Ligand		Sp.	Action	Value	Parameter	Reference
compound 7u [PMID: 24775305]		Hs	Inhibition	9.1	pIC₅₀	1
⤷	pIC₅₀ 9.1 (IC₅₀ 9x10^-10 M) [1]
compound 18 [PMID: 38090813]		Hs	Inhibition	8.1	pIC₅₀	2
⤷	pIC₅₀ 8.1 (IC₅₀ 7.8x10^-9 M) [2]

References

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1. Higgins C, Bouazzaoui S, Gaddale K, D'Costa Z, Templeman A, O'Rourke M, Young A, Scott C, Harrison T, Mullan P et al.. (2014) P3 SAR exploration of biphenyl carbamate based Legumain inhibitors. Bioorg Med Chem Lett, 24 (11): 2521-4. [PMID:24775305]

2. Krummenacher D, He W, Kuhn B, Schnider C, Beurier A, Brom V, Sivasothy T, Marty C, Tosstorff A, Hewings DS et al.. (2023) Discovery of Orally Available and Brain Penetrant AEP Inhibitors. J Med Chem, 66 (24): 17026-17043. [PMID:38090813]