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TLR5
Target has curated data in GtoImmuPdb
Target id: 1755
Nomenclature: TLR5
Family: Toll-like receptor family
Annotation status:
Awaiting annotation
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Contents:
- Quaternary Structure
- Gene and Protein Information
- Previous and Unofficial Names
- Database Links
- Selected 3D Structures
- Associated Proteins
- Enzyme Reaction
- Functional Characteristics
- Natural/Endogenous Ligands
- Rank order lists
- Activators
- Inhibitors
- Gating Inhibitors
- Agonists
- Antagonists
- Channel Blockers
- Allosteric Modulators
- Antibodies
- Other Binding Ligands
- Whole Organism Assay Data
- Large-scale Ligand Screening Data
- Immunopharmacology Comments
- Immuno Cell Type Associations
- Immuno Process Associations
- Immuno Disease Associations
- Malaria Pharmacology Comments
- Tissue Distribution
- Expression Datasets
- Functional Assays
- Physiological Functions
- Physiological Consequences of Altering Gene Expression
- Xenobiotics Influencing Gene Expression
- Phenotypes, Alleles and Disease Models
- Clinically-Relevant Mutations and Pathophysiology
- Gene Expression and Pathophysiology
- Biologically Significant Variants
- General Comments
- Available Assays
- References
- Contributors
- How to cite this page
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 858 | 1q41 | TLR5 | toll like receptor 5 | |
| Mouse | 1 | 859 | 1 86.12 cM | Tlr5 | toll-like receptor 5 | |
| Rat | - | - | 13q26 | Tlr5 | toll-like receptor 5 | |
| Previous and Unofficial Names |
| SLEB1 | TIL3 | Toll/interleukin-1 receptor-like protein 3 | toll-like receptor 5 | MELIOS | RP11-239E10.1 |
| Database Links |
|
| Alphafold | O60602 (Hs), Q9JLF7 (Mm) |
| CATH/Gene3D | 3.40.50.10140, 3.80.10.10 |
| ChEMBL Target | CHEMBL2176839 (Hs) |
| Ensembl Gene | ENSG00000187554 (Hs), ENSMUSG00000079164 (Mm), ENSRNOG00000022067 (Rn) |
| Entrez Gene | 7100 (Hs), 53791 (Mm), 289337 (Rn) |
| Human Protein Atlas | ENSG00000187554 (Hs) |
| KEGG Gene | hsa:7100 (Hs), mmu:53791 (Mm), rno:289337 (Rn) |
| OMIM | 603031 (Hs) |
| Pharos | O60602 (Hs) |
| UniProtKB | O60602 (Hs), Q9JLF7 (Mm) |
| Wikipedia | TLR5 (Hs) |
| Immunopharmacology Comments |
| TLR5 induces a pro-inflammatory response upon detection of extracellular bacterial flagellin from invading mobile bacteria [1]. In contrast, cytosolic flagellin in macrophages is recognised by NOD-like receptor NLRC4 (Ipaf). |
| Clinically-Relevant Mutations and Pathophysiology
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