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TLR3
Target has curated data in GtoImmuPdb
Target id: 1753
Nomenclature: TLR3
Family: Toll-like receptor family
Annotation status:
Awaiting annotation
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Contents:
- Quaternary Structure
- Gene and Protein Information
- Previous and Unofficial Names
- Database Links
- Selected 3D Structures
- Associated Proteins
- Enzyme Reaction
- Functional Characteristics
- Natural/Endogenous Ligands
- Rank order lists
- Activators
- Inhibitors
- Gating Inhibitors
- Agonists
- Antagonists
- Channel Blockers
- Allosteric Modulators
- Antibodies
- Other Binding Ligands
- Whole Organism Assay Data
- Large-scale Ligand Screening Data
- Immunopharmacology Comments
- Immuno Cell Type Associations
- Immuno Process Associations
- Immuno Disease Associations
- Malaria Pharmacology Comments
- Tissue Distribution
- Expression Datasets
- Functional Assays
- Physiological Functions
- Physiological Consequences of Altering Gene Expression
- Xenobiotics Influencing Gene Expression
- Phenotypes, Alleles and Disease Models
- Clinically-Relevant Mutations and Pathophysiology
- Gene Expression and Pathophysiology
- Biologically Significant Variants
- General Comments
- Available Assays
- References
- Contributors
- How to cite this page
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 904 | 4q35.1 | TLR3 | toll like receptor 3 | |
| Mouse | 1 | 905 | 8 B1.1 | Tlr3 | toll-like receptor 3 | |
| Rat | - | - | 16q11 | Tlr3 | toll-like receptor 3 | |
| Previous and Unofficial Names |
| toll-like receptor 3 | CD283 | IIAE2 |
| Database Links |
|
| Alphafold | O15455 (Hs), Q99MB1 (Mm) |
| CATH/Gene3D | 3.80.10.10, 3.40.50.10140 |
| ChEMBL Target | CHEMBL1075113 (Hs), CHEMBL2146340 (Mm) |
| Ensembl Gene | ENSG00000164342 (Hs), ENSMUSG00000031639 (Mm), ENSRNOG00000021726 (Rn) |
| Entrez Gene | 7098 (Hs), 142980 (Mm), 364594 (Rn) |
| Human Protein Atlas | ENSG00000164342 (Hs) |
| KEGG Gene | hsa:7098 (Hs), mmu:142980 (Mm), rno:364594 (Rn) |
| OMIM | 603029 (Hs) |
| Pharos | O15455 (Hs) |
| UniProtKB | O15455 (Hs), Q99MB1 (Mm) |
| Wikipedia | TLR3 (Hs) |
| Activator Comments | ||
| Poly(I:C) activation of TLR3 is assessed by its ability to induce cytokine production or activation of NF-κB and mitogen-activated protein (MAP) kinases [1]. |
| Immunopharmacology Comments |
| TLR3 is an endosomal anti-viral receptor [2], with potent pro-inflammatory actions (e.g. induction of Type I IFN and pro-inflammatory cytokines, including IL-6, TNF, IL-17, IL-21, IP-10 and RANTES). Innate Pharma are developing IPH33 as an anti-TLR3 anti-inflammatory biologic, which acts upstream relative to current therapies such as anti-TNF and anti-IL-6 mAbs and small molecule JAK inhibitors. |
| Clinically-Relevant Mutations and Pathophysiology
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References
1. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature, 413 (6857): 732-8. [PMID:11607032]
2. Uematsu S, Akira S. (2008) Toll-Like receptors (TLRs) and their ligands. Handb Exp Pharmacol, (183): 1-20. [PMID:18071652]
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