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Piezo2

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Not curated in GtoImmuPdb

Target id: 2946

Nomenclature: Piezo2

Family: Piezo channels

Annotation status:  image of a red circle Awaiting annotation  » Email us

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 37 2752 18p11.22-p11.21 PIEZO2 piezo type mechanosensitive ion channel component 2
Mouse 37 2822 18 E1 Piezo2 piezo-type mechanosensitive ion channel component 2
Rat - 2720 18q12.1 Piezo2 piezo-type mechanosensitive ion channel component 2
Gene and Protein Information Comments
Piezo proteins have between 24 and 36 predicted transmembrane domains.
Previous and Unofficial Names Click here for help
FAM38B | FAM38B2 | PIEZ2 | C18orf30
Database Links Click here for help
Alphafold Q9H5I5 (Hs), Q8CD54 (Mm)
CATH/Gene3D 1.25.10.10
Ensembl Gene ENSG00000154864 (Hs), ENSMUSG00000041482 (Mm), ENSRNOG00000038784 (Rn)
Entrez Gene 63895 (Hs), 667742 (Mm), 307380 (Rn)
Human Protein Atlas ENSG00000154864 (Hs)
KEGG Gene hsa:63895 (Hs), mmu:667742 (Mm), rno:307380 (Rn)
OMIM 613629 (Hs)
Orphanet ORPHA332055 (Hs)
Pharos Q9H5I5 (Hs)
RefSeq Nucleotide NM_022068 (Hs), NM_001039485 (Mm)
RefSeq Protein NP_071351 (Hs), NP_001034574 (Mm)
UniProtKB Q9H5I5 (Hs), Q8CD54 (Mm)
Wikipedia PIEZO2 (Hs)
Functional Characteristics Click here for help
Activation and deactivation, a few milliseconds; Inactivation, time constant 7 ms at -80 mV and slower at positive voltages; Unitary conductance, 24 pS; Ion selectivity, monovalent and divalent cations (PCa/PCs 1.34) - Mouse (Mm).
Endogenous modulators (Human)
Phosphatidic acid, palmitoyl lysophosphatidic acid
Physical activators (Human)
Cell indentation

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Voltage-dependent (mV) Reference
GsMTx-4 Peptide Click here for species-specific activity table Hs Inhibition 5.3 pIC50 - no 1
⤷ pIC50 5.3 [1]
Not voltage dependent
Gd3+ Click here for species-specific activity table Hs Inhibition - - - no 2
⤷ @ 30μM [2]
Not voltage dependent
ruthenium red Click here for species-specific activity table Hs Inhibition - - - no 2
⤷ @ 30 μM [2]
Not voltage dependent
propofol Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition - - - no 4
⤷ @ 50 μM [4]
Not voltage dependent
Physiological Functions Click here for help
Mediates vasomotion-triggered cluster firings in dorsal root ganglion neurons which triggers episodic neuropathic pain.
Species:  Mouse
Tissue: 
References:  3

References

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1. Alcaino C, Knutson K, Gottlieb PA, Farrugia G, Beyder A. (2017) Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4. Channels (Austin), 11 (3): 245-253. [PMID:28085630]

2. Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, Dubin AE, Patapoutian A. (2010) Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science, 330 (6000): 55-60. [PMID:20813920]

3. Xie W, Lückemeyer DD, Qualls KA, Prudente AS, Berta T, Gu M, Strong JA, Dong X, Zhang JM. (2025) Vascular motion in the dorsal root ganglion sensed by Piezo2 in sensory neurons triggers episodic pain. Neuron, 113 (11): 1774-1788.e5. [PMID:40154477]

4. Yu D, Bae C. (2025) Propofol inhibits Piezo mechanosensitive channels. Biophys J, [Epub ahead of print]. [PMID:40485107]

How to cite this page

Piezo channels: Piezo2. Last modified on 21/07/2025. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2946.