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IL-23   Click here for help

GtoPdb Ligand ID: 4978

Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-23 is an IL-12 family cytokine. Structurally it is a heterodimer consisting of IL-12B and IL-23A subunits.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Bioactivity Comments
IL-23 binds a heterodimeric receptor comprising an IL-12RP1 subunit (shared with the IL-12 receptor) and a unique receptor subunit, IL-23R. Receptor engagement activates JAK2 and Tyk2 to stimulate STAT1, -3, 4 and -5 signalling [5]. IL-23 plays an important role in bridging the innate and adaptive arms of the immune response [3].
The rationale for targeting the IL-23/IL-17/T helper type 17 (Th17) cell axis in the search for novel therapeutics for treating autoimmune inflammatory diseases is reviewed by Tang et al. (2012) [6], and further analysis of the role of IL-12 family cytokines in infection, inflammation and autoimmune disease is provided in [2].
Natural/Endogenous Targets
Target
Interleukin-23 receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-23 receptor Hs Agonist Agonist 7.4 – 10.5 pKd - 1,4
⤷ pKd 10.5 (Kd 3.16x10-11 M) [4]
Description: Binding affinity (NanoBRET)
pKd 7.4 (Kd 4.4x10-8 M) [1]
Description: Determined by microcalorimetry
Interleukin-23 receptor Ligand is endogenous in the given species Hs Agonist Agonist 9.6 pEC50 - 4
⤷ pEC50 9.6 (EC50 2.69x10-10 M) [4]
Description: Potency in inhbiting STAT3 phosphorylation by AlphaLISA