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F2L   Click here for help

GtoPdb Ligand ID: 3935

Compound class: Endogenous peptide in human, mouse or rat
Comment: F2L is an acetylated 21-aa cleavage protein of the N-terminal of haem-binding protein
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Devosse T, Dutoit R, Migeotte I, De Nadai P, Imbault V, Communi D, Salmon I, Parmentier M. (2011)
Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3.
J Immunol, 187 (3): 1475-85. [PMID:21709160]
2. Gao JL, Guillabert A, Hu J, Le Y, Urizar E, Seligman E, Fang KJ, Yuan X, Imbault V, Communi D et al.. (2007)
F2L, a peptide derived from heme-binding protein, chemoattracts mouse neutrophils by specifically activating Fpr2, the low-affinity N-formylpeptide receptor.
J Immunol, 178 (3): 1450-6. [PMID:17237393]
3. Migeotte I, Riboldi E, Franssen JD, Grégoire F, Loison C, Wittamer V, Detheux M, Robberecht P, Costagliola S, Vassart G et al.. (2005)
Identification and characterization of an endogenous chemotactic ligand specific for FPRL2.
J Exp Med, 201 (1): 83-93. [PMID:15623572]