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dihydrotestosterone   Click here for help

GtoPdb Ligand ID: 2856

Abbreviated name: DHT
Synonyms: 17β-hydroxy-5α-androstan-3-one | 5α-dihydrotestosterone | androstanolone | stanolone
PDB Ligand  verified structure
Compound class: Metabolite
Comment: Dihydrotestosterone is an androgenic metabolite of testosterone, it is the primary contributing factor in male pattern baldness.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: dihydrotestosterone

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 37.3
Molecular weight 290.22
XLogP 4.5
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES O=C1CCC2(C(C1)CCC1C2CCC2(C1CCC2O)C)C
Isomeric SMILES O=C1CC[C@]2([C@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C)C
InChI InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1
InChI Key NVKAWKQGWWIWPM-ABEVXSGRSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Natural/Endogenous Targets
Target
Androgen receptor
Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Androgen receptor Ligand is endogenous in the given species Hs Agonist Agonist 9.3 pKd - 17
⤷ pKd 9.3 (Kd 5x10-10 M) [17]
Androgen receptor Ligand is endogenous in the given species Rn Agonist Agonist 8.6 pIC50 - 5
⤷ pIC50 8.6 [5]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Rank order of potency at Androgen receptor dihydrotestosterone > testosterone
Endogenous agonists at ADGRD1 Peptides derived from the Stachel sequence: THLTNFAILMQVV; PLXDC2 is an activating ligand for mouse ADGRD1; dihydrotestosterone 2,11
Targets where the ligand is described in the comment field
Target Comment
ADGRD1 ADGRD1 a Gs protein-coupled receptor [3,11]. 5-α-dihydrotestosterone regulates skeletal muscle strength through the receptor. The same study establishes the small molecule agonist AP503 as an ADGRD1 specific and Gs-biased agonist [20]. Couples also to Gi proteins [12]. Strong association with body height [7-8,18] and bone mineral density [16]. Regulates oviductal fluid flow in mice [2]. The cryo-EM structure of the 7-helix transmembrane domain with its intramolecular agonist has been determined [14-15]. Expressed in the CNS [19], gastric antrum [6], thymus and adrenal glands [4], and intestinal epithelium [9]. ADGRD1 is highly expressed in glioblastoma [1]. Candidate SNP in lipid profiling [10] and SNP affecting electrocardiographic RR and QT interval [13]
Ligand mentioned in the following text fields
3C. 3-Ketosteroid receptors overview
Steroid hormone receptors overview