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d[Leu4Lys8]VP   Click here for help

GtoPdb Ligand ID: 2191

Synonyms: [deamino-Cys1,Leu4,Lys8]vasopressin | d[Leu4,Lys8]VP | d[Leu4]LVP | d[Leu4]lysine vasopressin
Compound class: Peptide
Comment: Synthetic analogue of lysine vasopressin
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Pena A, Murat B, Trueba M, Ventura MA, Bertrand G, Cheng LL, Stoev S, Szeto HH, Wo N, Brossard G et al.. (2007)
Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors.
Endocrinology, 148 (9): 4136-46. [PMID:17495006]
2. Pena A, Murat B, Trueba M, Ventura MA, Wo NC, Szeto HH, Cheng LL, Stoev S, Guillon G, Manning M. (2007)
Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8.
J Med Chem, 50: 835-847. [PMID:17300166]