mitochondrial peptide fMFADRW

GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

Home
Ligands
mitochondrial peptide fMFADRW

GtoPdb Ligand ID: 14144

Compound class: Peptide

Comment: This is an endogenous human mitochondrial cryptic hexapeptide with an N-terminal fMet [3]. It corresponds to the N terminus of cytochrome c oxidase subunit I. fMFADRW is a formyl peptide receptor agonist.

References
1. Gabl M, Sundqvist M, Holdfeldt A, Lind S, Mårtensson J, Christenson K, Marutani T, Dahlgren C, Mukai H, Forsman H. (2018) Mitocryptides from Human Mitochondrial DNA-Encoded Proteins Activate Neutrophil Formyl Peptide Receptors: Receptor Preference and Signaling Properties. J Immunol, 200 (9): 3269-3282. [PMID:29602776]
2. He HQ, Ye RD. (2017) The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition. Molecules, 22 (3). [PMID:28335409]
3. Rabiet MJ, Huet E, Boulay F. (2005) Human mitochondria-derived N-formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes-derived peptides preferentially activate FPR. Eur J Immunol, 35 (8): 2486-95. [PMID:16025565]

References

1. Gabl M, Sundqvist M, Holdfeldt A, Lind S, Mårtensson J, Christenson K, Marutani T, Dahlgren C, Mukai H, Forsman H. (2018)
Mitocryptides from Human Mitochondrial DNA-Encoded Proteins Activate Neutrophil Formyl Peptide Receptors: Receptor Preference and Signaling Properties.
J Immunol, 200 (9): 3269-3282. [PMID:29602776]

2. He HQ, Ye RD. (2017)
The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition.
Molecules, 22 (3). [PMID:28335409]

3. Rabiet MJ, Huet E, Boulay F. (2005)
Human mitochondria-derived N-formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes-derived peptides preferentially activate FPR.
Eur J Immunol, 35 (8): 2486-95. [PMID:16025565]