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butantoxin   Click here for help

GtoPdb Ligand ID: 14031

Synonyms: α-KTx12.1 [3]
Compound class: Peptide
Comment: Butantoxin (BuTX) is a 40 amino acid peptide toxin found in scorpion venom [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Holaday Jr SK, Martin BM, Fletcher Jr PL, Krishna NR. (2000)
NMR solution structure of butantoxin.
Arch Biochem Biophys, 379 (1): 18-27. [PMID:10864437]
2. Novello JC, Arantes EC, Varanda WA, Oliveira B, Giglio JR, Marangoni S. (1999)
TsTX-IV, a short chain four-disulfide-bridged neurotoxin from Tityus serrulatus venom which acts on Ca2+-activated K+ channels.
Toxicon, 37 (4): 651-60. [PMID:10082164]
3. Oyama Jr S, Pristovsek P, Franzoni L, Pertinhez TA, Schininá E, Lücke C, Rüterjans H, Arantes EC, Spisni A. (2005)
Probing the pH-dependent structural features of alpha-KTx12.1, a potassium channel blocker from the scorpion Tityus serrulatus.
Protein Sci, 14 (4): 1025-38. [PMID:15772309]