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nanobody Nb4   Click here for help

GtoPdb Ligand ID: 14009

Compound class: Antibody
Comment: Camelid nanobody Nb4 is reported as a positive allosteric modulator of the human calcium-sensing receptor [1]. It binds to the extracellular domain of CaSR.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Du W, Rahman SN, Barker E, Bräuner-Osborne H, Mathiesen JM, Ward DT, Jensen AA. (2025)
Detailed functional characterization of four nanobodies as positive allosteric modulators of the human calcium-sensing receptor.
Biochem Pharmacol, 231: 116619. [PMID:39522703]