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domvanalimab   Click here for help

GtoPdb Ligand ID: 13983

Synonyms: AB-154 | AB154
Immunopharmacology Ligand
Compound class: Antibody
Comment: Domvanalimab (AB154) is an anti-TIGIT monoclonal antibody. It is designed to be 'Fc-silent' as a method to prevent depletiion of regulatory T cells (which would otherwise be promoted by Fc-mediated antibody dependent cellular cytotoxicity). Silencing TIGIT has two functions. It negates the inhibitory action of TIGIT binding to poliovirus receptor (PVR, CD155) which blocks immune suppression, and it leaves PVR available to interact with the costimulatory DNAM-1 (CD226) molecule. The combined effects potentiate a natural killer (NK) cell and T cell-mediated anti-tumour immune response.
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
TIGIT Hs Antibody Binding - - - 1
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