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annexin I-(2-26)   Click here for help

GtoPdb Ligand ID: 1044

Synonyms: annexin I, Ac2-26 | annexin-derived peptide | ANXA1-derived peptide
Compound class: Endogenous peptide in human, mouse or rat
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Ernst S, Lange C, Wilbers A, Goebeler V, Gerke V, Rescher U. (2004)
An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family.
J Immunol, 172 (12): 7669-76. [PMID:15187149]
2. Gabl M, Sundqvist M, Holdfeldt A, Lind S, Mårtensson J, Christenson K, Marutani T, Dahlgren C, Mukai H, Forsman H. (2018)
Mitocryptides from Human Mitochondrial DNA-Encoded Proteins Activate Neutrophil Formyl Peptide Receptors: Receptor Preference and Signaling Properties.
J Immunol, 200 (9): 3269-3282. [PMID:29602776]
3. Gavins FN, Yona S, Kamal AM, Flower RJ, Perretti M. (2003)
Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms.
Blood, 101 (10): 4140-7. [PMID:12560218]
4. Hayhoe RP, Kamal AM, Solito E, Flower RJ, Cooper D, Perretti M. (2006)
Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement.
Blood, 107 (5): 2123-30. [PMID:16278303]
5. He HQ, Ye RD. (2017)
The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition.
Molecules, 22 (3). [PMID:28335409]
6. Perretti M, Chiang N, La M, Fierro IM, Marullo S, Getting SJ, Solito E, Serhan CN. (2002)
Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor.
Nat Med, 8 (11): 1296-302. [PMID:12368905]
7. Rabiet MJ, Huet E, Boulay F. (2005)
Human mitochondria-derived N-formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes-derived peptides preferentially activate FPR.
Eur J Immunol, 35 (8): 2486-95. [PMID:16025565]
8. Sogawa Y, Ohyama T, Maeda H, Hirahara K. (2011)
Formyl peptide receptor 1 and 2 dual agonist inhibits human neutrophil chemotaxis by the induction of chemoattractant receptor cross-desensitization.
J Pharmacol Sci, 115 (1): 63-8. [PMID:21173551]
9. Walther A, Riehemann K, Gerke V. (2000)
A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR.
Mol Cell, 5 (5): 831-40. [PMID:10882119]
10. Ye RD, Boulay F, Wang JM, Dahlgren C, Gerard C, Parmentier M, Serhan CN, Murphy PM. (2009)
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family.
Pharmacol Rev, 61 (2): 119-61. [PMID:19498085]
11. Yi X, Tran E, Odiba JO, Qin CX, Ritchie RH, Baell JB. (2024)
The formyl peptide receptors FPR1 and FPR2 as targets for inflammatory disorders: recent advances in the development of small-molecule agonists.
Eur J Med Chem, 265: 115989. [PMID:38199163]