ulixacaltamide [Ligand Id: 7718] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3934636 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cav3.1/Voltage-gated T-type calcium channel alpha-1G subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4641] [GtoPdb: 535] [UniProtKB: O43497] | ||||||||
| GtoPdb | - | - | 7.3 | pIC50 | - | - | - | Sci Transl Med (2012) 4: 121ra19 [PMID:22344687] |
| ChEMBL | Inhibition of T-type calcium channel Cav3.1 (unknown origin) expressed in HEK293 cells assessed as calcium influx by Fluo-4-AM dye-based FLIPR assay | B | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (2016) 59: 8398-8411 [PMID:27579577] |
| ChEMBL | Inhibition of human CaV 3.1 by manual patch clamp assay | B | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (2016) 59: 10661-10675 [PMID:27933950] |
| ChEMBL | Inhibition of Cav3.1 (unknown origin) | B | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (2023) 66: 4434-4467 [PMID:37012671] |
| Cav3.2/Voltage-gated T-type calcium channel alpha-1H subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1859] [GtoPdb: 536] [UniProtKB: O95180] | ||||||||
| GtoPdb | - | - | 6.8 | pIC50 | - | - | - | Sci Transl Med (2012) 4: 121ra19 [PMID:22344687] |
| ChEMBL | Inhibition of recombinant T-type calcium channel Cav3.2 (unknown origin) expressed in HEK293 cells assessed as inhibition of CaCl2-induced calcium influx preincubated for 3 mins prior CaCl2 addition by Fluo-4-AM dye-based FLIPR assay | B | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (2016) 59: 8398-8411 [PMID:27579577] |
| ChEMBL | Inhibition of human CaV 3.2 by manual patch clamp assay | B | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (2016) 59: 10661-10675 [PMID:27933950] |
| ChEMBL | Inhibition of Cav3.2 (unknown origin) | B | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (2023) 66: 4434-4467 [PMID:37012671] |
| Cav3.3/Voltage-gated T-type calcium channel alpha-1I subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5558] [GtoPdb: 537] [UniProtKB: Q9P0X4] | ||||||||
| GtoPdb | - | - | 7 | pIC50 | - | - | - | Sci Transl Med (2012) 4: 121ra19 [PMID:22344687] |
| ChEMBL | Inhibition of T-type calcium channel Cav3.3 (unknown origin) expressed in HEK293 cells assessed as calcium influx by Fluo-4-AM dye-based FLIPR assay | B | 7.07 | pIC50 | 86 | nM | IC50 | J Med Chem (2016) 59: 8398-8411 [PMID:27579577] |
| ChEMBL | Inhibition of human CaV 3.3 by manual patch clamp assay | B | 7.07 | pIC50 | 86 | nM | IC50 | J Med Chem (2016) 59: 10661-10675 [PMID:27933950] |
| ChEMBL | Inhibition of Cav3.3 (unknown origin) | B | 7.07 | pIC50 | 86 | nM | IC50 | J Med Chem (2023) 66: 4434-4467 [PMID:37012671] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
