magnolol [Ligand Id: 14021] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL180920 (Magnolol) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| aldehyde dehydrogenase 2 family member/Aldehyde dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1935] [GtoPdb: 2595] [UniProtKB: P05091] | ||||||||
| ChEMBL | Agonist activity at human recombinant ALDH2 measured after 1 hr | B | 4.24 | pEC50 | 57900 | nM | EC50 | Bioorg Med Chem Lett (2021) 43: 128045-128045 [PMID:33865968] |
| CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
| ChEMBL | Displacement of [3H]CP55,940 from recombinant human CB1 receptor expressed in CHO cells after 2 hrs by liquid scintillation counting | B | 5.5 | pKi | 3150 | nM | Ki | ACS Med Chem Lett (2013) 4: 41-45 [PMID:24900561] |
| ChEMBL | Partial agonist activity at recombinant human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation at 100 uM after 5 mins by cAMP-competition binding assay relative to CP55,940 | F | 4.74 | pEC50 | 18300 | nM | EC50 | ACS Med Chem Lett (2013) 4: 41-45 [PMID:24900561] |
| CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
| ChEMBL | Displacement of [3H]CP55,940 from recombinant human CB2 receptor expressed in CHO cells after 2 hrs by liquid scintillation counting | B | 5.84 | pKi | 1440 | nM | Ki | ACS Med Chem Lett (2013) 4: 41-45 [PMID:24900561] |
| ChEMBL | Partial agonist activity at recombinant human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation at 100 uM after 5 mins by cAMP-competition binding assay relative to CP55,940 | F | 5.48 | pEC50 | 3280 | nM | EC50 | ACS Med Chem Lett (2013) 4: 41-45 [PMID:24900561] |
| GABAA receptor α1 subunit/GABAA receptor γ2 subunit/GABAA receptor β2 subunit/GABA-A receptor; alpha-1/beta-2/gamma-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095172] [GtoPdb: 404, 414, 411] [UniProtKB: P14867, P18507, P47870] | ||||||||
| ChEMBL | Positive allosteric modulation of GABAA alpha1beta2gamma2 receptor (unknown origin) stably expressed in CHO cells assessed as activation of GABA-induced response in presence of GABA by FLIPR assay | B | 5.32 | pEC50 | 4800 | nM | EC50 | J Nat Prod (2022) 85: 1201-1210 [PMID:35475609] |
| GABAA receptor α1 subunit/GABAA receptor β2 subunit/GABA-A receptor; GABA-A site (alpha1/beta2 interface) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907597] [GtoPdb: 404, 411] [UniProtKB: P14867, P47870] | ||||||||
| ChEMBL | Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique | B | 4.43 | pEC50 | 36800 | nM | EC50 | J Med Chem (2011) 54: 5349-5361 [PMID:21699169] |
| Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181] | ||||||||
| ChEMBL | Agonist activity at PPARdelta (unknown origin) | B | 4.94 | pEC50 | 11410 | nM | EC50 | Eur J Med Chem (2021) 221: 113535-113535 [PMID:33992930] |
| Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
| ChEMBL | Agonist activity at PPARgamma (unknown origin) | B | 5.79 | pEC50 | 1620 | nM | EC50 | Eur J Med Chem (2021) 221: 113535-113535 [PMID:33992930] |
| ChEMBL | Agonist activity at PPARgamma (unknown origin) | B | 6.34 | pEC50 | 458 | nM | EC50 | Eur J Med Chem (2021) 221: 113535-113535 [PMID:33992930] |
| KCa1.1 in Human [GtoPdb: 380] [UniProtKB: Q12791] | ||||||||
| GtoPdb | - | - | 6 | pEC50 | ~1000 | nM | EC50 | Thorax (2002) 57: 67-74 [PMID:11809993] |
| K2P1.1 in Human [GtoPdb: 513] [UniProtKB: O00180] | ||||||||
| GtoPdb | - | - | 5.21 | pIC50 | 6200 | nM | IC50 | Molecules (2023) 28: [PMID:37836658] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
