BAY-277 [Ligand Id: 13974] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL5465171 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Methionyl aminopeptidase 2/Methionine aminopeptidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3922] [GtoPdb: 1573] [UniProtKB: P50579] | ||||||||
| ChEMBL | 2D HUVEC cells proliferation assay | F | 7.92 | pIC50 | 12 | nM | IC50 | Data for DCP probe BAY-277 |
| ChEMBL | METAP2 biochemical assay (human) | B | 8.24 | pIC50 | 5.8 | nM | IC50 | Data for DCP probe BAY-277 |
| GtoPdb | - | - | 8.24 | pIC50 | 5.8 | nM | IC50 | Overview for BAY-277 a degrader of METAP2. thesgc.org |
| Methionyl aminopeptidase 2/Methionine aminopeptidase 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075272] [GtoPdb: 1573] [UniProtKB: O08663] | ||||||||
| ChEMBL | METAP2 biochemical assay (mouse) | B | 8.23 | pIC50 | 5.9 | nM | IC50 | Data for DCP probe BAY-277 |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
