zegocractin [Ligand Id: 10087] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4753998 (Cm 4620, CM-4620, CM4620, Zegocractin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Orai1/ORAI1/STIM1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3832644] [GtoPdb: 2964] [UniProtKB: Q13586, Q96D31] | ||||||||
| GtoPdb | In vitro inhibition of calcium entry mediated by Orai1/STIM1 CRAC channels. | - | 6.92 | pIC50 | 119 | nM | IC50 |
WO2016138472A1. Pancreatitis treatment (2016); Pancreas (2021) 50: 537-543 [PMID:33939666] |
| ChEMBL | Inhibition of Orai1/STIM1 (unknown origin) | B | 6.92 | pIC50 | 119 | nM | IC50 | J Med Chem (2021) 64: 17004-17030 [PMID:34843241] |
| Orai2/Protein orai-2/Stromal interaction molecule 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4888450] [GtoPdb: 2965] [UniProtKB: Q13586, Q96SN7] | ||||||||
| ChEMBL | Inhibition of Orai2/STIM1 (unknown origin) | B | 6.05 | pIC50 | 895 | nM | IC50 | J Med Chem (2021) 64: 17004-17030 [PMID:34843241] |
| GtoPdb | In vitro inhibition of calcium entry mediated by Orai2/STIM1 CRAC channels. | - | 6.05 | pIC50 | 895 | nM | IC50 | WO2016138472A1. Pancreatitis treatment (2016) |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
