Type XVII RTKs: ROS receptors | Catalytic receptors | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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Type XVII RTKs: ROS receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The ROS1 gene encodes a receptor tyrosine kinase, whose endogenous substrate and normal physiological functions are not fully determined, however there is evidence that neural epidermal growth factor-like like 2 (NELL2; Q99435) is an agonist for ROS1. Aberrant expression and mutated forms of ROS1 are drivers of malignant transformation in number of tumour types.

Receptors

Targets of relevance to immunopharmacology are highlighted in blue

ROS (c-ros oncogene 1, receptor tyrosine kinase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1840

Nomenclature

c-ros oncogene 1, receptor tyrosine kinase

Common abbreviation

ROS

Previous and unofficial names

Genes

ROS1 (Hs), Ros1 (Mm), Ros1 (Rn)

Ensembl ID

ENSG00000047936 (Hs), ENSMUSG00000019893 (Mm), ENSRNOG00000000406 (Rn)

UniProtKB AC

P08922 (Hs), Q78DX7 (Mm), Q63132 (Rn)

EC number

2.7.10.1

Comments

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Citation information

Database page citation:

Type XVII RTKs: ROS receptors. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=796.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.