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- Calcium- and sodium-activated potassium channels (KCa, KNa)
Calcium- and sodium-activated potassium channels (KCa, KNa) C
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
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Calcium- and sodium- activated potassium channels are members of the 6TM family of K channels which comprises the voltage-gated KV subfamilies, including the KCNQ subfamily, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 6 or 7TM) and the Ca2+- and Na+-activated SK subfamily (nomenclature as agreed by the NC-IUPHAR Subcommittee on Calcium- and sodium-activated potassium channels [31]). As for the 2TM family, the pore-forming a subunits form tetramers and heteromeric channels may be formed within subfamilies (e.g. KV1.1 with KV1.2; KCNQ2 with KCNQ3).
Channels and Subunits
Targets of relevance to immunopharmacology are highlighted in blue
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KCa1.1 C
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KCa2.1 C
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KCa2.2 C
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KCa2.3 C
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KCa3.1
C
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KNa1.1 C
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KNa1.2 C
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KCa5.1 C
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Further reading
* Key recommended reading is highlighted with an asterisk
* Brown BM, Shim H, Christophersen P, Wulff H. (2020) Pharmacology of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels. Annu Rev Pharmacol Toxicol, 60: 219-240. [PMID:31337271]
* Dopico AM, Bukiya AN, Jaggar JH. (2018) Calcium- and voltage-gated BK channels in vascular smooth muscle. Pflugers Arch, 470 (9): 1271-1289. [PMID:29748711]
* Kaczmarek LK, Aldrich RW, Chandy KG, Grissmer S, Wei AD, Wulff H. (2017) International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels. Pharmacol Rev, 69 (1): 1-11. [PMID:28267675]
* Kshatri AS, Gonzalez-Hernandez A, Giraldez T. (2018) Physiological Roles and Therapeutic Potential of Ca2+ Activated Potassium Channels in the Nervous System. Front Mol Neurosci, 11: 258. [PMID:30104956]
References
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NC-IUPHAR subcommittee and family contributors
Subcommittee members:
Leonard K. Kaczmarek (Chairperson)
Richard Aldrich
K. George Chandy
Stephan Grissmer
Aguan D. Wei
Heike Wulff |
Other contributors:
George A. Gutman |
Citation information
Database page citation (select format):
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Mathie AA, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Ion channels. Br J Pharmacol. 180 Suppl 2:S145-S222.
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