Miscellaneous SLC25 mitochondrial transporters | Transporters | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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SLC superfamily of solute carriers
SLC25 family of mitochondrial transporters
Miscellaneous SLC25 mitochondrial transporters

Miscellaneous SLC25 mitochondrial transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Many of the transporters identified below have yet to be assigned functions and are currently regarded as orphans.

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

mitochondrial carrier 1 / SLC25A49 C Show summary »« Hide summary

Target Id	2554
Nomenclature	mitochondrial carrier 1
Systematic nomenclature	SLC25A49
Previous and unofficial names	mitochondrial carrier homolog 1 (C. elegans) \| Presenilin-associated protein \| PSAP \| SLC25A49 \| solute carrier family 25, member 49
Genes	MTCH1 (Hs), Mtch1 (Mm), Mtch1 (Rn)
Ensembl ID	ENSG00000137409 (Hs), ENSMUSG00000024012 (Mm), ENSRNOG00000000527 (Rn)
UniProtKB AC	Q9NZJ7 (Hs), Q791T5 (Mm)
Bioparadigms SLC Tables	SLC25A49 (Hs)
RESOLUTE	MTCH1 (Hs)

mitochondrial carrier 2 / SLC25A50 C Show summary »« Hide summary

Target Id	2555
Nomenclature	mitochondrial carrier 2
Systematic nomenclature	SLC25A50
Previous and unofficial names	SLC25A50 \| solute carrier family 25, member 50 \| Met-induced mitochondrial protein \| mitochondrial carrier homolog 2 (C. elegans)
Genes	MTCH2 (Hs), Mtch2 (Mm), Mtch2 (Rn)
Ensembl ID	ENSG00000109919 (Hs), ENSMUSG00000027282 (Mm), ENSRNOG00000058658 (Rn)
UniProtKB AC	Q9Y6C9 (Hs), Q791V5 (Mm)
Bioparadigms SLC Tables	SLC25A50 (Hs)
RESOLUTE	MTCH2 (Hs)

solute carrier family 25 member 53 / SLC25A53 Show summary »« Hide summary

Target Id	2562
Nomenclature	solute carrier family 25 member 53
Systematic nomenclature	SLC25A53
Previous and unofficial names	MCART6 \| mitochondrial carrier triple repeat 6 \| Mcart1l \| mitochondrial carrier triple repeat 1-like \| solute carrier family 25, member 53 \| solute carrier family 25
Genes	SLC25A53 (Hs), Slc25a53 (Mm), Slc25a53 (Rn)
Ensembl ID	ENSG00000269743 (Hs), ENSMUSG00000044348 (Mm), ENSRNOG00000069699 (Rn)
UniProtKB AC	Q5H9E4 (Hs)
Bioparadigms SLC Tables	SLC25A53 (Hs)
RESOLUTE	SLC25A53 (Hs)

SLC25A46 C Show summary »« Hide summary

Mitochondrial choline transporter / SLC25A48 C Show summary »« Hide summary

Target Id

2559

Nomenclature

Mitochondrial choline transporter

Systematic nomenclature

SLC25A48

Previous and unofficial names

solute carrier family 25, member 48 | solute carrier family 25

Genes

SLC25A48 (Hs), Slc25a48 (Mm), Slc25a48 (Rn)

Ensembl ID

ENSG00000145832 (Hs), ENSMUSG00000021509 (Mm), ENSRNOG00000012040 (Rn)

UniProtKB AC

Q6ZT89 (Hs), Q8BW66 (Mm)

Bioparadigms SLC Tables

SLC25A48 (Hs)

RESOLUTE

SLC25A48 (Hs)

Substrates

choline [1-3]

Stoichiometry

choline (in)

References

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1. Maity S, Sharma K. (2025) The mitochondrial choline transporter, SLC25A48, regulates urine and blood choline levels in humans. Kidney Int, 107 (2): 225-227. [PMID:39848743]

2. Patil S, Borisov O, Scherer N, Wirth C, Schlosser P, Wuttke M, Ehret S, Hannibal L, Eckardt KU, Hunte C et al.. (2025) The membrane transporter SLC25A48 enables transport of choline into human mitochondria. Kidney Int, 107 (2): 296-301. [PMID:39084256]

3. Verkerke ARP, Shi X, Li M, Higuchi Y, Yamamuro T, Katoh D, Nishida H, Auger C, Abe I, Gerszten RE et al.. (2024) SLC25A48 controls mitochondrial choline import and metabolism. Cell Metab, 36 (9): 2156-2166.e9. [PMID:39111307]

Citation information

Database page citation:

Miscellaneous SLC25 mitochondrial transporters. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=209.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.