Mitochondrial nucleotide transporter subfamily | Transporters | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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SLC superfamily of solute carriers
SLC25 family of mitochondrial transporters
Mitochondrial nucleotide transporter subfamily

Mitochondrial nucleotide transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Mitochondrial nucleotide transporters, defined by structural similarlities, include the adenine nucleotide translocator family (SLC25A4, SLC25A5, SLC25A6 and SLC25A31), which under conditions of aerobic metabolism, allow coupling between mitochondrial oxidative phosphorylation and cytosolic energy consumption by exchanging cytosolic ADP for mitochondrial ATP. Further members of the mitochondrial nucleotide transporter subfamily convey diverse substrates including CoA, although not all members have had substrates identified.

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

ANT1 (Mitochondrial adenine nucleotide translocator 1 / SLC25A4) C Show summary »« Hide summary

Target Id

1062

Nomenclature

Mitochondrial adenine nucleotide translocator 1

Systematic nomenclature

SLC25A4

Common abbreviation

ANT1

Previous and unofficial names

ADP,ATP carrier protein 1 | ADP,ATP carrier protein, heart/skeletal muscle isoform T1 | PEO2 | PEO3 | T1 | ADP/ATP translocase 1 | solute carrier family 25 (mitochondrial adenine nucleotide translocator) member 4 | adenine nucleotide translocase-1 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 | solute carrier family 25 (mitochondrial carrier

Genes

SLC25A4 (Hs), Slc25a4 (Mm), Slc25a4 (Rn)

Ensembl ID

ENSG00000151729 (Hs), ENSMUSG00000031633 (Mm), ENSRNOG00000010830 (Rn)

UniProtKB AC

P12235 (Hs), P48962 (Mm), Q05962 (Rn)

Bioparadigms SLC Tables

SLC25A4 (Hs)

RESOLUTE

SLC25A4 (Hs)

Inhibitors

carboxyatractyloside

bongkrek acid

Stoichiometry

ADP^3- (in) : ATP^4- (out)

Comment

Structures of yeast SLC25A4 bound to bongkrekic acid (PDB 6GCI) [3] or carboxyaractyloside (PDB 6GCI) [2] have been deposited to the Protein Data Bank (PDB). SLC25A4 is an off-target for chebulinic acid, CD-437 and suramin [1].

ANT2 (Mitochondrial adenine nucleotide translocator 2 / SLC25A5) C Show summary »« Hide summary

Target Id	1063
Nomenclature	Mitochondrial adenine nucleotide translocator 2
Systematic nomenclature	SLC25A5
Common abbreviation	ANT2
Previous and unofficial names	2F1 \| T2 \| T3 \| adenine nucleotide translocator 2 fibroblast isoform (ATP-ADP carrier protein) \| solute carrier family 25 member 5 \| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 \| solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 \| solute carrier family 25 (mitochondrial carrier
Genes	SLC25A5 (Hs), Slc25a5 (Mm), Slc25a5 (Rn)
Ensembl ID	ENSG00000005022 (Hs), ENSMUSG00000016319 (Mm), ENSRNOG00000039980 (Rn)
UniProtKB AC	P05141 (Hs), P51881 (Mm), Q09073 (Rn)
Bioparadigms SLC Tables	SLC25A5 (Hs)
RESOLUTE	SLC25A5 (Hs)
Stoichiometry	ADP^3- (in) : ATP^4- (out)

ANT3 (Mitochondrial adenine nucleotide translocator 3 / SLC25A6) C Show summary »« Hide summary

Target Id	1064
Nomenclature	Mitochondrial adenine nucleotide translocator 3
Systematic nomenclature	SLC25A6
Common abbreviation	ANT3
Previous and unofficial names	Adenine nucleotide translocator 2 \| ADP,ATP carrier protein 3 \| ADP,ATP carrier protein, isoform T2 \| ANT3Y \| adenine nucleotide translocator), member 6 \| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 \| Slc25a6 \| solute carrier family 25 member 6
Genes	SLC25A6 (Hs), Slc25a5-ps11 (Rn)
Ensembl ID	ENSG00000169100 (Hs), ENSRNOG00000042387 (Rn)
UniProtKB AC	P12236 (Hs)
Bioparadigms SLC Tables	SLC25A6 (Hs)
RESOLUTE	SLC25A6 (Hs)
Stoichiometry	ADP^3- (in) : ATP^4- (out)

ANT4 (Mitochondrial adenine nucleotide translocator 4 / SLC25A31) C Show summary »« Hide summary

Target Id	1065
Nomenclature	Mitochondrial adenine nucleotide translocator 4
Systematic nomenclature	SLC25A31
Common abbreviation	ANT4
Previous and unofficial names	Sperm flagellar energy carrier protein \| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 \| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator)
Genes	SLC25A31 (Hs), Slc25a31 (Mm), Slc25a31 (Rn)
Ensembl ID	ENSG00000151475 (Hs), ENSMUSG00000069041 (Mm), ENSRNOG00000038398 (Rn)
UniProtKB AC	Q9H0C2 (Hs), Q3V132 (Mm)
Bioparadigms SLC Tables	SLC25A31 (Hs)
RESOLUTE	SLC25A31 (Hs)
Stoichiometry	ADP^3- (in) : ATP^4- (out)

GDC (Graves disease carrier / SLC25A16) C Show summary »« Hide summary

Target Id

1071

Nomenclature

Graves disease carrier

Systematic nomenclature

SLC25A16

Common abbreviation

GDC

Previous and unofficial names

Genes

SLC25A16 (Hs), Slc25a16 (Mm), Slc25a16 (Rn)

Ensembl ID

ENSG00000122912 (Hs), ENSMUSG00000071253 (Mm), ENSRNOG00000000387 (Rn)

UniProtKB AC

P16260 (Hs), Q8C0K5 (Mm), P16261 (Rn)

Bioparadigms SLC Tables

SLC25A16 (Hs)

RESOLUTE

SLC25A16 (Hs)

Substrates

CoA and congeners

Stoichiometry

CoA (in)

PMP34 (Peroxisomal membrane protein / SLC25A17) C Show summary »« Hide summary

Target Id

1072

Nomenclature

Peroxisomal membrane protein

Systematic nomenclature

SLC25A17

Common abbreviation

PMP34

Previous and unofficial names

peroxisomal membrane protein (34kD) | peroxisomal membrane protein PMP34 | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 | solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17 | solute carrier family 25 (mitochondrial carrier

Genes

SLC25A17 (Hs), Slc25a17 (Mm), Slc25a17 (Rn)

Ensembl ID

ENSG00000100372 (Hs), ENSMUSG00000022404 (Mm), ENSRNOG00000018920 (Rn)

UniProtKB AC

O43808 (Hs), O70579 (Mm)

Bioparadigms SLC Tables

SLC25A17 (Hs)

RESOLUTE

SLC25A17 (Hs)

Substrates

ADP

ATP

adenosine 5'-monophosphate

Stoichiometry

ATP (in)

APC1 (Mitochondrial ATP-Mg/phosphate carrier 1 / SLC25A24) C Show summary »« Hide summary

Target Id

1077

Nomenclature

Mitochondrial ATP-Mg/phosphate carrier 1

Systematic nomenclature

SLC25A24

Common abbreviation

APC1

Previous and unofficial names

calcium-binding mitochondrial carrier protein SCaMC-1 | solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 | solute carrier family 25 (mitochondrial carrier

Genes

SLC25A24 (Hs), Slc25a24 (Mm), Slc25a24 (Rn)

Ensembl ID

ENSG00000085491 (Hs), ENSMUSG00000040322 (Mm), ENSRNOG00000020470 (Rn)

UniProtKB AC

Q6NUK1 (Hs), Q8BMD8 (Mm)

Bioparadigms SLC Tables

SLC25A24 (Hs)

RESOLUTE

SLC25A24 (Hs)

Substrates

Mg-bound adenosine nucleotides

phosphate

Stoichiometry

Mg-ATP in : inorganic phosphate (Pi) out

APC2 (Mitochondrial ATP-Mg/phosphate carrier 2 / SLC25A23) C Show summary »« Hide summary

Target Id

1078

Nomenclature

Mitochondrial ATP-Mg/phosphate carrier 2

Systematic nomenclature

SLC25A23

Common abbreviation

APC2

Previous and unofficial names

APC2 | calcium-binding mitochondrial carrier protein SCaMC-3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 | solute carrier family 25 (mitochondrial carrier; phosphate carrier)

Genes

SLC25A23 (Hs), Slc25a23 (Mm), Slc25a23 (Rn)

Ensembl ID

ENSG00000125648 (Hs), ENSMUSG00000046329 (Mm), ENSRNOG00000047781 (Rn)

UniProtKB AC

Q9BV35 (Hs), Q6GQS1 (Mm)

Bioparadigms SLC Tables

SLC25A23 (Hs)

RESOLUTE

SLC25A23 (Hs)

Substrates

Mg-bound adenosine nucleotides

phosphate

Stoichiometry

Mg-ATP in : inorganic phosphate (Pi) out

APC3 (Mitochondrial ATP-Mg/phosphate carrier 3 / SLC25A25) C Show summary »« Hide summary

Target Id

1079

Nomenclature

Mitochondrial ATP-Mg/phosphate carrier 3

Systematic nomenclature

SLC25A25

Common abbreviation

APC3

Previous and unofficial names

MCSC | PCSCL | ATP-Mg/Pi carrier | calcium-binding mitochondrial carrier protein SCaMC-2 | mitochondrial ATP-Mg/Pi carrier protein | mitochondrial Ca2+-dependent solute carrier | small calcium-binding mitochondrial carrier protein 2 | solute carrier family 25 member 25 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 | solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 | solute carrier family 25 (mitochondrial carrier

Genes

SLC25A25 (Hs), Slc25a25 (Mm), Slc25a25 (Rn)

Ensembl ID

ENSG00000148339 (Hs), ENSMUSG00000026819 (Mm), ENSRNOG00000014338 (Rn)

UniProtKB AC

Q6KCM7 (Hs), A2ASZ8 (Mm), Q8K3P6 (Rn)

Bioparadigms SLC Tables

SLC25A25 (Hs)

RESOLUTE

SLC25A25 (Hs)

Substrates

Mg-bound adenosine nucleotides

phosphate

Stoichiometry

Mg-ATP in : inorganic phosphate (Pi) out

APC4 (Mitochondrial ATP-Mg/phosphate carrier 4 / SLC25A41) C Show summary »« Hide summary

Target Id

1092

Nomenclature

Mitochondrial ATP-Mg/phosphate carrier 4

Systematic nomenclature

SLC25A41

Common abbreviation

APC4

Previous and unofficial names

APC4 | mitochondrial ATP-Mg/Pi carrier protein | solute carrier family 25 member 41 | solute carrier family 25

Genes

SLC25A41 (Hs), Slc25a41 (Mm), Slc25a41 (Rn)

Ensembl ID

ENSG00000181240 (Hs), ENSMUSG00000011486 (Mm), ENSRNOG00000048853 (Rn)

UniProtKB AC

Q8N5S1 (Hs), Q8BVN7 (Mm)

Bioparadigms SLC Tables

SLC25A41 (Hs)

RESOLUTE

SLC25A41 (Hs)

Substrates

Mg-bound adenine nucleotides

phosphate

Stoichiometry

Mg-ATP in : inorganic phosphate (Pi) out

PNC1 (Mitochondrial pyrimidine nucleotide transporter 1 / SLC25A33) C Show summary »« Hide summary

Target Id

1084

Nomenclature

Mitochondrial pyrimidine nucleotide transporter 1

Systematic nomenclature

SLC25A33

Common abbreviation

PNC1

Previous and unofficial names

BMSC-MCP | solute carrier family 25 member 33 | solute carrier family 25 (pyrimidine nucleotide carrier), member 33 | solute carrier family 25

Genes

SLC25A33 (Hs), Slc25a33 (Mm), Slc25a33 (Rn)

Ensembl ID

ENSG00000171612 (Hs), ENSMUSG00000028982 (Mm), ENSRNOG00000016949 (Rn)

UniProtKB AC

Q9BSK2 (Hs), Q3TZX3 (Mm)

Bioparadigms SLC Tables

SLC25A33 (Hs)

RESOLUTE

SLC25A33 (Hs)

Substrates

uracil, thymine, and cytosine (deoxy)nucleoside di- and tri-phosphates

PNC2 (Mitochondrial pyrimidine nucleotide transporter 2 / SLC25A36) C Show summary »« Hide summary

Target Id

1087

Nomenclature

Mitochondrial pyrimidine nucleotide transporter 2

Systematic nomenclature

SLC25A36

Common abbreviation

PNC2

Previous and unofficial names

solute carrier family 25, member 36 | solute carrier family 25 (pyrimidine nucleotide carrier ), member 36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | solute carrier family 25

Genes

SLC25A36 (Hs), Slc25a36 (Mm), Slc25a36 (Rn)

Ensembl ID

ENSG00000114120 (Hs), ENSMUSG00000032449 (Mm), ENSRNOG00000013802 (Rn)

UniProtKB AC

Q96CQ1 (Hs), Q922G0 (Mm)

Bioparadigms SLC Tables

SLC25A36 (Hs)

RESOLUTE

SLC25A36 (Hs)

Substrates

cytosine and uracil (deoxy)nucleoside mono-, di, and tri-phosphates

SLC25A43 Show summary »« Hide summary

Target Id	1093
Systematic nomenclature	SLC25A43
Previous and unofficial names	solute carrier family 25, member 43 \| solute carrier family 25
Genes	SLC25A43 (Hs), Slc25a43 (Mm)
Ensembl ID	ENSG00000077713 (Hs), ENSMUSG00000037636 (Mm)
UniProtKB AC	Q8WUT9 (Hs), A2A3V2 (Mm)
Bioparadigms SLC Tables	SLC25A43 (Hs)
RESOLUTE	SLC25A43 (Hs)

References

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1. Jaiquel Baron S, King MS, Kunji ERS, Schirris TJJ. (2021) Characterization of drug-induced human mitochondrial ADP/ATP carrier inhibition. Theranostics, 11 (11): 5077-5091. [PMID:33859735]

2. Ruprecht JJ, Hellawell AM, Harding M, Crichton PG, McCoy AJ, Kunji ER. (2014) Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism. Proc Natl Acad Sci U S A, 111 (4): E426-34. [PMID:24474793]

3. Ruprecht JJ, King MS, Zögg T, Aleksandrova AA, Pardon E, Crichton PG, Steyaert J, Kunji ERS. (2019) The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier. Cell, 176 (3): 435-447.e15. [PMID:30611538]

Citation information

Database page citation:

Mitochondrial nucleotide transporter subfamily. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=206.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.

Mitochondrial nucleotide transporter subfamily C

Overview

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

Further reading

References

Citation information